HORDB

ID: hor003026
Uniprot ID: Q0VBW8
Protein name: Neuromedin-S
Gene name: NMS
Organism: Bos taurus (Bovine)
Family: NmU family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: FWRRDSRATAADFTKKDYTATLGRPFFLFRPRN
Length: 33(104-136)
Propeptide: MKYLAQFPSILAIYCFCLLQIPSSGFPRPLADASDGLDIVKFEQMAYWASLSRQPKDNQDIYKRFLFHYSRTQEPAHPVKTGFPPVHPLMRLAAKLADRRMKTFWRRDSRATAADFTKKDYTATLGRPFFLFRPRNGRNLDFDTW
Signal peptide: MKYLAQFPSILAIYCFCLLQIPSSG
Modification: T33 Asparagine amide
Glycosylation: NA
Mutagenesis: NA

Function: Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.
Mechanism: NA
Cross BBB: NA
Target: NMUR1
Target Unid: F1MY53
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q8LAD7-F1.pdb

hor003026_AF2.pdb

hor003026_ESM.pdb

Mass:	458048	Formula:	C184H275N55O47
Absent amino acids:	CEHIMQV	Common amino acids:	R
pI:	11.88	Basic residues:	8
Polar residues:	8	Hydrophobic residues:	12
Hydrophobicity:	-89.09	Boman Index:	-11199
Half-Life / Aliphatic Index:	1.1 hour	Aliphatic Index:	35.76
Instability Index:	5026.06	Extinction Coefficient cystines:	6990
Absorbance 280nm:	218.44